Welcome to AmericanHotels.co's selection of luxury hotels in Ponce , Puerto Rico. We offer a range of options from hotels and resorts to apartments, allowing you to stay close to the city's top attractions, such as Museo Castillo Serrallés, Casino De Ponce , Museo De Arte De Ponce and Panteón Nacional Román Baldorioty de Castro. Enjoy a stroll through La Fuente del León or visit Catedral Nuestra Señora de Guadalupe for a dose of culture and history. Whether you want to relax on the beach or explore Ponce's popular areas, you can find the perfect place to stay when you book with us. Get great deals on stays at some of the finest hotels in Puerto Rico when you book today on AmericanHotels.co!