Welcome to AmericanHotels.co's luxury hotel listings for Murrells Inlet, SC, USA. Our selection of 16+ hotels offers something for everyone - from cozy boutique hotels and luxurious resorts to spacious apartments. Enjoy world-class attractions nearby such as the Murrells Inlet Marsh Walk, Atalaya Castle, Crazy Sister Marina - Fishing Charters & Watersports, Inlet Adventure, TPC Myrtle Beach and Broadway at the Beach. No matter what kind of experience you're looking for in Murrells Inlet, you'll find it at AmericanHotels.co. Offering unbeatable prices and a commitment to quality service and hospitality, AmericanHotels.co is your go-to source for finding luxurious accommodation in this vibrant coastal town. Book now to take advantage of our incredible savings!