AmericanHotels.co offers the finest selection of luxury accommodations in Isle of Palms, SC, USA. From plush resorts to cozy apartments, we have something for every traveler. Enjoy amazing views and a plethora of activities at the nearby attractions like Isle of Palms County Park, Rainbow Row, Lighthouse Inlet Heritage Preserve, Beachside Excursions, Morris Island Lighthouse, and South Carolina Aquarium. Take advantage of our exclusive deals and discounts when you book directly with us on AmericanHotels.co and save big on your stay! With top-notch amenities such as heated pools, spas, fitness centers, fine dining restaurants and more – you'll never have to leave the hotel to have a great time! Choose one of our 21+ luxury hotels for the ultimate travel experience!